Friday, 16 October 2015

Next #GeriMedJC on Oct 23 at 08:00 EDT

The October #GeriMedJC will take place on the 23rd at 08:00 Eastern / noon GMT.  We will tackle two interesting articles.  

Did you know that the live version of the Geriatric Medicine Journal Club held at the University of Toronto, is on the fourth Friday of the month from 08:00-09:00 ET? Postgraduate subspecialty trainees in Geriatric Medicine take turns leading the critical appraisal.  The first 45 minutes of the hour is devoted to the presentation and discussion of the long article and the latter 15 minutes is reserved for presentation and appraisal of the short article. The live version is also broadcast to several different hospitals in several different cities via the Ontario Telemedicine Network.

#GeriMedJC, the Twitter-complement to the traditional format journal club, has been up and running for over a year.  The intention is to engage an international dialogue across all time zones as a tweetchat should have no time restrictions.  


The first (long) article will look at hip fracture care models.  The link to the article can be accessed here.



Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial.Lancet. 2015 Apr 25;385(9978):1623-33.


BACKGROUND:

Most patients with hip fractures are characterised by older age (>70 years), frailty, and functional deterioration, and their long-term outcomes are poor with increased costs. We compared the effectiveness and cost-effectiveness of giving these patients comprehensive geriatric care in a dedicated geriatric ward versus the usual orthopaedic care.

METHODS:

We did a prospective, single-centre, randomised, parallel-group, controlled trial. Between April 18, 2008, and Dec 30, 2010, we randomly assigned home-dwelling patients with hip-fractures aged 70 years or older who were able to walk 10 m before their fracture, to either comprehensive geriatric care or orthopaedic care in the emergency department, to achieve the required sample of 400 patients. Randomisation was achieved via a web-based, computer-generated, block method with unknown block sizes. The primary outcome, analysed by intention to treat, was mobility measured with the Short Physical Performance Battery (SPPB) 4 months after surgery for the fracture. The type of treatment was not concealed from the patients or staff delivering the care, and assessors were only partly masked to the treatment during follow-up. This trial is registered with ClinicalTrials.gov, number NCT00667914.

FINDINGS:

We assessed 1077 patients for eligibility, and excluded 680, mainly for not meeting the inclusion criteria such as living in a nursing home or being aged less than 70 years. Of the remaining patients, we randomly assigned 198 to comprehensive geriatric care and 199 to orthopaedic care. At 4 months, 174 patients remained in the comprehensive geriatric care group and 170 in the orthopaedic care group; the main reason for dropout was death. Mean SPPB scores at 4 months were 5·12 (SE 0·20) for comprehensive geriatric care and 4·38 (SE 0·20) for orthopaedic care (between-group difference 0·74, 95% CI 0·18-1·30, p=0·010).

INTERPRETATION:

Immediate admission of patients aged 70 years or more with a hip fracture to comprehensive geriatric care in a dedicated ward improved mobility at 4 months, compared with the usual orthopaedic care. The results suggest that the treatment of older patients with hip fractures should be organised as orthogeriatric care.


For the second (short) article, we'll take a look at medical education. Great news!  The full text is available free here:


Medical students' and doctors' attitudes towards older patients and their care in hospital settings: a conceptualisation. Age Ageing. 2015 Sep;44(5):776-83. 


BACKGROUND:

despite assertions in reports from governmental and charitable bodies that negative staff attitudes towards older patients may contribute to inequitable healthcare provision for older patients when compared with younger patients (those aged under 65 years), the research literature does not describe these attitudes in any detail.

OBJECTIVE:

this study explored and conceptualised attitudes towards older patients using in-depth interviews.

METHODS:

twenty-five semi-structured interviews with medical students and hospital-based doctors in a UK acute teaching hospital were conducted. Participants were asked about their beliefs, emotions and behavioural tendencies towards older patients, in line with the psychological literature on the definition of attitudes (affective, cognitive and behavioural information). Data were analysed thematically.

RESULTS:

attitudes towards older patients and their care could be conceptualised under the headings: (i) beliefs about older patients; (ii) older patients' unique needs and the skills required to care for them and (iii) emotions and satisfaction with caring for older patients.

CONCLUSIONS:


our findings outlined common beliefs and stereotypes specific to older patients, as opposed to older people in general. Older patients had unique needs concerning their healthcare. Participants typically described negative emotions about caring for older patients, but the sources of dissatisfaction largely related to the organisational setting and system in which the care is delivered to these patients. This study marks one of the first in-depth attempts to explore attitudes towards older patients in UK hospital settings.


Saturday, 26 September 2015

These tweeps love #GeriMedJC and we hope you do too!

It's been just over a year since we launched #GeriMedJC, the Twitter complement to the traditional format Geriatric Medicine journal club at the University of Toronto.  Reflecting on the experience, these are some tweets about #GeriMedJC that illustrate the interest:

What could be more fun than #GeriMedJC on a Friday morning?  We've had fun this year, and hopefully you have too!

As Geriatric Medicine trainees come and go, it's great to see they take #GeriMedJC with them to their new locations of practice.

We're thrilled to have social media in medicine gurus like Bernadette Keefe join in and retweet to her wider audience:

Even though the live version of #GeriMedJC is in Toronto, Canada, it's great to learn that our colleagues across the pond are at least lurking!

Even when #GeriMedJC fans are vacationing in Disney World, the most magical place on earth, there's time for #GeriMedJC.  Take that, Mickey Mouse!

And even after a year of participating in the live version of #GeriMedJC through the Ontario Telehealth Network, we're glad to hear participants seeing the added value of the Twitter complement.  We think it's a great medical education, advocacy and networking tool and hope you do too!

We look forward to another year of international engagement!  Thanks, tweeps!

A great turnout for Sep 2015 #GeriMedJC

The first half-hour of the live version of #GeriMedJC was facilitated by Amanda Gardhouse (@agardhouse), a Geriatric Medicine postgraduate trainee at the University of Toronto.  After conducting a focus group mid-way through out first year of #GeriMedJC, we learned that one of the barriers to faculty and trainee engagement on #GeriMedJC was due to a lack of familiarity with Twitter.  We gained 33 new followers since the last month, of which many were faculty in our division at the university.  Welcome tweeps!

During the second hour, this article was critically appraised:


Mossello E, Pieraccioli M, Nesti N, Bulgaresi M, Lorenzi C, Caleri V, Tonon E, Cavallini MC, Baroncini C, Di Bari M, Baldasseroni S, Cantini C, Biagini CA, Marchionni N, Ungar A.Effects of low blood pressure in cognitively impaired elderly patients treated with antihypertensive drugs. JAMA Intern Med. 2015 Apr;175(4):578-85. 

Overall, the audience thought the conclusions may have been a bit of a stretch and the follow-up was on the short side.  Nevertheless, caution should be raised in the setting of low blood pressure.  View the entire tweet chat transcript here.  Thank you to all the participants for making this one of the biggest #GeriMedJC sessions!



We're grateful to Dr. Bernadette Keefe (@nxtstop1), social media in medicine guru, from North Carolina who storified this discussion (click here)!

We'll see you next time on #GeriMedJC (October 30, 2015 at 08:00 ET / 12:00 GMT).

Thursday, 17 September 2015

Something a bit different for the September 2015 #GeriMedJC

Did you know that the live version of the Geriatric Medicine Journal Club held at the University of Toronto, is on the last Friday of the month from 08:00-09:00 ET?  Postgraduate subspecialty trainees in Geriatric Medicine take turns leading the critical appraisal.  Article selection is guided by a clinician-scientist.  The first 45 minutes of the hour is devoted to the presentation and discussion of the long article and the latter 15 minutes is reserved for presentation and appraisal of the short article. The live version is also broadcast to several different hospitals in several different cities via the Ontario Telemedicine Network.

#GeriMedJC, the Twitter-complement to the traditional format journal club, has been up and running for over a year.  The intention is to engage an international dialogue across all time zones as a tweetchat should have no time restrictions.  

We obtained feedback about the first year's experience from our postgraduate trainees and faculty. One of the challenges was hesitancy to engage on the Twitter medium due to unfamiliarity with Twitter. However, there was recognition and appreciation for #GeriMedJC to engage international experts and dialogue. Therefore, in the September 2015 live version of #GeriMedJC, we will be devoting the first half of the hour on how to get started on using Twitter for journal clubs as well as tips for the advanced tweep.  In the meantime, check out our cool new infographic, How to #GeriMedJC. Another feedback suggestion was to have a repository of the previous articles and transcripts of the tweet chats much like the #RheumJC and #NephJC folks.  Look out for our new #GeriMedJC website which is under construction!  

Since the first half of the hour of this month's live #GeriMedJC will be devoted to How to #GeriMedJC, the critical appraisal of the short article will commence at 08:30 ET / 12:30 GMT. 

The association between blood pressure and cognitive function remains controversial with studies showing mixed results.  This may yet be another example of 'not one size fits all'. People are individuals, not numbers.



Mossello E, Pieraccioli M, Nesti N, Bulgaresi M, Lorenzi C, Caleri V, Tonon E, Cavallini MC, Baroncini C, Di Bari M, Baldasseroni S, Cantini C, Biagini CA, Marchionni N, Ungar A.Effects of low blood pressure in cognitively impaired elderly patients treated with antihypertensive drugs. JAMA Intern Med. 2015 Apr;175(4):578-85. 

PMID: 25730775

Access the article here or read the abstract below:

IMPORTANCE:
The prognostic role of high blood pressure and the aggressiveness of blood pressure lowering in dementia are not well characterized.

OBJECTIVE:
To assess whether office blood pressure, ambulatory blood pressure monitoring, or the use of antihypertensive drugs (AHDs) predict the progression of cognitive decline in patients with overt dementia and mild cognitive impairment (MCI).

DESIGN, SETTING, AND PARTICIPANTS:
Cohort study between June 1, 2009, and December 31, 2012, with a median 9-month follow-up of patients with dementia and MCI in 2 outpatient memory clinics.

MAIN OUTCOMES AND MEASURES:
Cognitive decline, defined as a Mini-Mental State Examination (MMSE) score change between baseline and follow-up.

RESULTS:
We analyzed 172 patients, with a mean (SD) age of 79 (5) years and a mean (SD) MMSE score of 22.1 (4.4). Among them, 68.0% had dementia, 32.0% had MCI, and 69.8% were being treated with AHDs. Patients in the lowest tertile of daytime systolic blood pressure (SBP) (≤ 128 mm Hg) showed a greater MMSE score change (mean [SD], -2.8 [3.8]) compared with patients in the intermediate tertile (129-144 mm Hg) (mean [SD], -0.7 [2.5]; P = .002) and patients in the highest tertile (≥ 145 mm Hg) (mean [SD], -0.7 [3.7]; P = .003). The association was significant in the dementia and MCI subgroups only among patients treated with AHDs. In a multivariable model that included age, baseline MMSE score, and vascular comorbidity score, the interaction term between low daytime SBP tertile and AHD treatment was independently associated with a greater cognitive decline in both subgroups. The association between office SBP and MMSE score change was weaker. Other ambulatory blood pressure monitoring variables were not associated with MMSE score change.

CONCLUSIONS AND RELEVANCE:
Low daytime SBP was independently associated with a greater progression of cognitive decline in older patients with dementia and MCI among those treated with AHDs. Excessive SBP lowering may be harmful for older patients with cognitive impairment. Ambulatory blood pressure monitoring can be useful to help avoid high blood pressure overtreatment in this population.

Can't join us live? No worries!  Engage in the discussion on Twitter on August 28, 2015 at 08:00 ET / 12:00 GMT and don't forget to use the hashtag #GeriMedJC.

Wednesday, 16 September 2015

Want to #GeriMedJC, but don't know how? Check out our new infographic!


A special thanks to Thomas Galati, a Masters of Computer Science student at UOIT!

Study author joins us for a successful August 2015 #GeriMedJC

The two articles critically appraised and discussed during the August 2015 #GeriMedJC were:

Delayed-start analysis: Mild Alzheimer's disease patients in solanezumab trials, 3.5 years. Alzheimer's & Dementia: Translational Research & Clinical Interventions. In press. 2015. 

Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015 May 28;372(22):2087-96. 

It was a nice treat to have one of the study authors from the Zoster vaccine trial, Dr. Jan McElhaney, join us live via the Ontario Telemedicine Network and Twitter (@vitality_md) for commentary.

We continue to grow and now have close to 550 followers!

Missed the discussion?  You can get the transcript of the #GeriMedJC tweet chat here.

Thanks again to all those who participated in the Tweet chat:

You may also view articles discussed at prior #GeriMedJC tweetchats at PubMed Commons. (link) The next #GeriMedJC will be on September 25, 2015 at 08:00 ET / noon GMT. Stay tuned for the articles!

Monday, 24 August 2015

August 2015 #GeriMedJC articles

This month we will be discussing two articles. In the live version of the Geriatric Medicine Journal Club held at the University of Toronto, the first 45 minutes of the hour is devoted to the presentation and discussion of the long article and the latter 15 minutes is reserved for presentation and appraisal of the short article.

Did you know that the live version of #GeriMedJC runs for an hour and is broadcast to several different hospitals in four different cities via the Ontario Telemedicine Network? 

Toronto: Mount Sinai Hospital, Sunnybrook Hospital, St. Michael’s Hospital, Baycrest Hospital, North York General Hospital, St. Joseph’s Hospital
Mississauga: Trillium Hospital
Kitchener-Waterloo: Grand River Hospital, St. Mary's Hospital
Orillia: Soldier's Memorial Hospital

Can't join us live? No worries!  Engage in the discussion on Twitter on August 28, 2015 at 08:00 EDT / 12:00 GMT and don't forget to use the hashtag #GeriMedJC.


The long article this month should provide an interesting discussion on study design and statistical methodology.  This study utilizes a delayed-start, also known as randomized-start, to demonstrate disease-modification drug effect.  We will take a look at this study of an investigational treatment for mild Alzheimer's disease:


Delayed-start analysis: Mild Alzheimer's disease patients in solanezumab trials, 3.5 years. Alzheimer's & Dementia: Translational Research & Clinical Interventions. In press. 2015. 

Access the article here or read the abstract below:

Introduction
Solanezumab is an anti-amyloid monoclonal antibody in clinical testing for treatment of Alzheimer's disease (AD). Its mechanism suggests the possibility of slowing the progression of AD.

Methods
A possible disease-modifying effect of solanezumab was assessed using a new statistical method including noninferiority testing. Performance differences were compared during the placebo-controlled period with performance differences after the placebo patients crossed over to solanezumab in the delayed-start period.

Results
Noninferiority of the 14-item Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog14) and Alzheimer's Disease Cooperative Study Activities of Daily Living inventory instrumental items (ADCS-iADL) differences was met through 132 weeks, indicating that treatment differences observed in the placebo-controlled period remained, within a predefined margin, after the placebo group initiated solanezumab. Solanezumab was well tolerated, and no new safety concerns were identified.

Discussion

The results of this secondary analysis show that the mild subgroup of solanezumab-treated patients who initiated treatment early, at the start of the placebo-controlled period, retained an advantage at most time points in the delayed-start period.



The short article discussion will follow the long article discussion.  The currently available live-attenuated vaccine against herpes zoster has two major limitations: diminishing efficacy against shingles with increasing age of vaccine recipients and contraindication for use in immunocompromised individuals.  Could recombinant subunit vaccines fill in this gap?  In this month's #GeriMedJC, the following trial will be appraised.


Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015 May 28;372(22):2087-96. 

PMID: 25916341

Access the article here or read the abstract below:

BACKGROUND:
In previous phase 1-2 clinical trials involving older adults, a subunit vaccine containing varicella-zoster virus glycoprotein E and the AS01B adjuvant system (called HZ/su) had a clinically acceptable safety profile and elicited a robust immune response.

METHODS:
We conducted a randomized, placebo-controlled, phase 3 study in 18 countries to evaluate the efficacy and safety of HZ/su in older adults (≥50 years of age), stratified according to age group (50 to 59, 60 to 69, and ≥70 years). Participants received two intramuscular doses of the vaccine or placebo 2 months apart. The primary objective was to assess the efficacy of the vaccine, as compared with placebo, in reducing the risk of herpes zoster in older adults.

RESULTS:
A total of 15,411 participants who could be evaluated received either the vaccine (7698 participants) or placebo (7713 participants). During a mean follow-up of 3.2 years, herpes zoster was confirmed in 6 participants in the vaccine group and in 210 participants in the placebo group (incidence rate, 0.3 vs. 9.1 per 1000 person-years) in the modified vaccinated cohort. Overall vaccine efficacy against herpes zoster was 97.2% (95% confidence interval [CI], 93.7 to 99.0; P<0.001). Vaccine efficacy was between 96.6% and 97.9% for all age groups. Solicited reports of injection-site and systemic reactions within 7 days after vaccination were more frequent in the vaccine group. There were solicited or unsolicited reports of grade 3 symptoms in 17.0% of vaccine recipients and 3.2% of placebo recipients. The proportions of participants who had serious adverse events or potential immune-mediated diseases or who died were similar in the two groups.

CONCLUSIONS:
The HZ/su vaccine significantly reduced the risk of herpes zoster in adults who were 50 years of age or older. Vaccine efficacy in adults who were 70 years of age or older was similar to that in the other two age groups.